Everyone wants to age like fine wine but premature signs of aging pop up and spoil the game. Luckily, the best argireline serums can help you fight against them all. Argireline is a key ingredient in these serums and it’s renowned for its anti-aging properties. 

According to a paper published in the National Library of Medicine, argireline is a non-toxic, anti-wrinkle peptide that can be considered a safe and effective alternative to Botulinum neurotoxins (BoNTs) used in cosmetic products for anti-aging benefits. Based on our observation, a serum infused with argireline is basically a botox packed in a bottle. What makes it the rockstar ingredient in serums? It aids in promoting elastin and collagen production that paves the way for plumper-looking skin. Moreover, it is a sip of water for your skin which promises moisture retention. Talking about its anti-aging benefits, it minimizes the appearance of crow’s feet, fine lines, and wrinkles. 

Moreover, these serums are armed not only with this superhero but also with a few other hydrating ingredients like hyaluronic acid, peptides, ceramides, niacinamide, algae extracts, vitamins, and other collagen-boosting goodies.

Based on our observations, some serums with argireline can be considered to be growth factor serums since they serve us with an enviable youthful radiance. 

So, there is no reason to wait any longer. Join us on our journey while we analyze, test, and review the best serums for achieving healthy and hydrated skin.  Let the shopping spree get started!

• 1
  Best Overall

  The Ordinary Argireline Solution 10%

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Target the appearance of dynamic facial lines with this fantastic argireline serum introduced by The Ordinary. This serum is truly a magical potion to uplift dull and tired skin. With the goodness of peptides, it works towards stimulating collagen production and thus, improves the overall elasticity of your skin. In addition, potassium carbonate guarantees freshness, and propanediol keeps your skin hydrated and thoroughly moisturized. What’s cool? It has a lightweight gel-like texture that gets absorbed quickly. 

Size: 1oz

Skin Type: Normal, dry, combination, and oily

2

Editor’s Pick

IQ Natural Martixyl 3000 Triple Power Serum

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Enriched with hydrating ingredients like hyaluronic acid, argireline, and martixyl, this serum from IQ Natural is like a dose of hydration. It is not just a mere everyday anti-aging serum, it is the go-to for tackling wrinkles and fine lines that leave your skin feeling supple, firm, and tightened. This elixir stimulates collagen production and promotes youthful and healthy-looking skin. We found that this serum feels comfortable on the skin whether you use it during the day or night.

Size: 1oz

Skin Type: All

3

Best Growth Factor Serum

SKIN DEVA 20% Argireline Serum with HA

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Skin Deva has truly mastered the art of skincare as it is power-packed with all the right ingredients that your skin needs. With Matrixyl 3000, hyaluronic acid, and argireline, it serves you with remarkable and visible results. What’s special? It increases collagen production for unveiling youthful, smooth, and fresh skin. Based on our observation, this serum reduces the appearance of wrinkles, crow’s feet, and cutaneous photodamage which ultimately tightens your skin. For all good reasons, this serum is renowned as a growth factor serum. 

Size: 1oz

Skin Type: Oily, combination, dry, normal

4

Best for Skin Tightening

Eva Naturals Matrixyl 3000 Argireline Vitamin C Skin Repairing Serum

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This skin-repairing serum from Eva Naturals is a sheer skincare fairy godmother. You can call it an anti-aging serum, a plumping serum, or a skin-tightening serum, its splendid results will never disappoint you. With its collagen-boosting formula, it keeps wrinkles at bay, while vitamin C acts as a potent antioxidant to protect your skin against pollutants and environmental stressors. That’s not all — this serum also aids in reducing dark spots and hyperpigmentation and ultimately lends you healthy, radiant, and hydrated skin. 

Size: 2oz

Skin Type: Combination

5

Most Cost-effective

Derma Clinicals Multi Peptide Firming Serum

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Moving on to the next masterpiece, Derma Clinicals’ firming serum! This serum is known for providing effective solutions as it is crafted from superstar ingredients like Matrixyl 3000, argireline, vitamin C, and hyaluronic acid that repair aged cells and protect against further damage. Plus, it lends sufficient nourishment, relaxes tension and facial muscles, and reduces skin damage caused by free radicals. Summing everything up, this innovative skincare essential is to attain glowing skin. 

Size: 4oz

Skin Type: All

6

Best for Delaying the Signs of Aging

QRxLabs Collagen Serum

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Delaying the signs of aging is easily possible with the Collagen Serum introduced by QRxLabs. Enriched with hydrolyzed rice protein, chamomile, and green tea extracts, it increases the elasticity of your skin, reduces fine lines and wrinkles, and improves overall moisture retention.  If you ask us, this serum is your ticket to achieving the skin of your dreams. It is not only about fighting against aging but also caring for the skin with its skin-soothing properties.

Size: 1oz

Skin Type: All

7

Best for Evening Out Skin Tone

Dr Nolan Argireline Serum

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Based on our first-hand research, a couple of users have labeled this serum as the best matrixyl and argireline serum for attaining a more balanced and even-toned complexion. When you apply this serum to your face religiously you will notice a significant difference. It basically uncovers the potential of your skin and leaves it looking more youthful, supple, and dewy. To note more, this revolutionary serum incorporates a higher concentration of active peptides and comes with a blend of 5% hyaluronic acid and 2% vitamin C for sustained hydration. Hence, there is a reduction of fine lines, wrinkles, and other signs of aging. 

Size: 1oz

Skin Type: All

8

Best for Dry and Aging Skin

Depology Peptide Complex 10% Wrinkle Defense Serum

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Lend your skin an extra dose of aging prevention and defense with Depology’s Peptide Complex 10% Wrinkle Defense Serum. This serum has transformative powers that rejuvenate your skin from within. All credit goes to its impeccable blend of key ingredients such as hyaluronic acid, chamomile, fig extract, cica, heartleaf, and vitamins C and E. Additionally, its exceptional formula effortlessly integrates into any skincare regime and specifically prevents fine lines, wrinkles, crow’s feet, and other signs of aging. 

Size: 1.01oz

Skin Type: All

Quick Tip:

Apply the serum to cleansed, toned skin for optimal results. You can use it during the day as well as at night for visible results.

9

Best for dull skin

Principal Secret Reclaim Hydrating Complex Emergency Rescue Serum

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The Emergency Rescue Serum from Principal Secret transcends conventional skincare boundaries. Crafted mindfully, its potent formula goes a step further than hydration and safeguards your skin against future moisture loss. Argireline molecular complex, hyaluronic acid, and wrinkle-fighting ingredients make this serum the beacon of innovation as it improves skin firmness, clarity, and elasticity. Not to forget, the ceramides present in the serum keep skin inflammation and dehydration at bay. While glancing through its reviews section we found that those who use it swear by it.

Size: 0.51oz

Skin Type: Dry

Quick Tip:

Apply a sufficient quantity of serum on your face and neck. Make sure you have cleansed and toned your face before application.

10

Best for Tightening Saggy Skin

Babyface Firming Serum

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Okay, so here is our scoop — Babyface’s firming serum is the holy grain for tightening saggy skin. It is an anti-aging powerhouse that stimulates collagen production and is one of the most remarkable skin-smoothening serums that decreases the appearance of fine lines and wrinkles. What’s more? This skincare essential aims to improve the appearance of age spots and dark circles under the eyes. Well, it is the perfect blend of  Matrixyl 3000 and Argireline, and the potent formula of the serum takes you a step closer to achieving smooth, supple, silky-soft skin. 

Size: 1.3oz

Skin Type: All

That was our comprehensive list of the best argireline products. Now, let us run you through a detailed buying guide.

Here are a few aspects that you should consider before splurging on the best argireline serum.

Skin Type and Skin Concerns: Make sure you analyze your skin type before investing in any of the best serums with argireline for skin. For anyone who has sensitive skin, opt for serums that are gentle, mild, and effective. Likewise, for anyone who is dealing with oily and combination skin, it is advisable to rely on serums that are non-comedogenic and hypoallergenic. Once you understand your skin type and concerns, it will help you know what your skin needs the most.

Ingredients: If you are dealing with skin dullness, dehydration, and aging, look for powerhouses like hyaluronic acid, vitamin C, peptides, chamomile, botanical extracts, etc. along with argireline. They are indeed the superheroes that will help you target specific skin concerns and thereby promote skin elasticity, retain moisture, and prevent future skin damage. 

Formula: Pay heed to the formula of the serums that you are planning to buy. It is wise to pick those that possess a non-irritating and dermatologically-tested formula. Plus, it is a bonus if the serum is free from parabens, silicones, phthalates, sulfates, and artificial fragrances.

Texture: Choose serums that have non-sticky, non-greasy, and quick absorbent texture. Addedly, they should be light on the skin and easy to glide. 

Once you have found your perfect pick, you can rely on the following tips for accurate application.

Following are some steps to apply the serum for effective results.

Step 1: Make sure you cleanse your face thoroughly with a high-grade face wash or cleanser. 

Step 2: Once you wash off deeply-seated impurities, pat dry your skin with a micro-fiber towel gently. 

Step 3: Apply your everyday toner.

Step 4: Pour a pea-sized amount of the argireline serum or use the dropper/applicator for accurate application. 

Step 5: Apply a few drops onto your cheeks, neck, forehead, and nose. Pay heed to the areas that require more TLC. 

Step 6: Gentle pat it on your skin and wait a few minutes until the serum is fully absorbed. 

Step 7: Follow it up with your moisturizer and then sunscreen.

Tada, you are done!